Gianfranco Alpini Selected Research

Cholestasis

11/2021	Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling.
1/2021	The Apelin-Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis.
11/2020	The Role of Lymphatics in Cholestasis: A Comprehensive Review.
1/2020	Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.
12/2019	The challenges of primary biliary cholangitis: What is new and what needs to be done.
1/2019	Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
11/2017	Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.
10/2017	Regulators of Cholangiocyte Proliferation.
1/2017	Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells.
12/2016	Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice.

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Gianfranco Alpini Research Topics

Disease

45	Fibrosis (Cirrhosis) 01/2022 - 05/2002
38	Cholestasis 11/2021 - 05/2002
35	Neoplasms (Cancer) 01/2022 - 12/2005
33	Cholangiocarcinoma 04/2021 - 06/2002
31	Inflammation (Inflammations) 01/2022 - 10/2004
31	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 02/2009
28	Liver Diseases (Liver Disease) 01/2022 - 10/2004
18	Sclerosing Cholangitis 03/2022 - 05/2002
16	Hyperplasia 01/2022 - 05/2007
14	Non-alcoholic Fatty Liver Disease 01/2022 - 12/2012
8	Carcinogenesis 11/2021 - 05/2008
7	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2021 - 09/2012
5	Fatty Liver 10/2021 - 02/2014
5	Liver Neoplasms (Liver Cancer) 01/2021 - 04/2006
5	Disease Progression 11/2020 - 05/2008
4	Obesity 01/2022 - 12/2015
4	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/2019 - 05/2002
4	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 04/2006
4	Necrosis 05/2015 - 10/2004
3	Insulin Resistance 01/2021 - 12/2018
3	Body Weight (Weight, Body) 01/2018 - 08/2009
3	Ischemia 01/2018 - 11/2007
3	Cysts 11/2016 - 02/2008
3	Autosomal Dominant Polycystic Kidney (ADPKD) 11/2016 - 02/2008
3	Fistula 06/2014 - 04/2002
2	Alcoholic Fatty Liver 01/2022 - 01/2020
2	Neoplasm Metastasis (Metastasis) 07/2021 - 04/2006
2	Wounds and Injuries (Trauma) 04/2020 - 01/2018

Drug/Important Bio-Agent (IBA)

16	Bile Acids and Salts (Bile Acids)IBA 03/2022 - 05/2002
15	Histamine (Histamine Dihydrochloride)FDA Link 03/2022 - 06/2010
14	Secretin FDA Link 10/2021 - 04/2003
13	MicroRNAs (MicroRNA)IBA 11/2020 - 12/2011
13	Proteins (Proteins, Gene)FDA Link 11/2020 - 05/2007
12	CytokinesIBA 01/2021 - 07/2003
11	MelatoninIBA 01/2022 - 10/2011
11	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 12/2005
9	secretin receptorIBA 10/2021 - 04/2010
9	Hormones (Hormone)IBA 01/2019 - 07/2007
7	CollagenIBA 01/2022 - 12/2005
7	Phosphotransferases (Kinase)IBA 01/2021 - 07/2013
7	MorpholinosIBA 11/2020 - 01/2017
7	Messenger RNA (mRNA)IBA 11/2020 - 05/2006
7	Biological ProductsIBA 11/2020 - 01/2007
7	Bicarbonates (Hydrogen Carbonate)IBA 01/2019 - 04/2002
6	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2018 - 02/2008
5	LipidsIBA 10/2021 - 04/2007
5	FructoseIBA 01/2021 - 01/2018
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2018
5	Adenosine (Adenocard)FDA LinkGeneric 12/2018 - 05/2007
5	EnzymesIBA 10/2017 - 11/2008
4	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 06/2002
4	Substance PIBA 11/2020 - 08/2011
4	Vascular Endothelial Growth Factor CIBA 01/2020 - 12/2005
4	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 01/2005
4	Histamine Receptors (Histamine Receptor)IBA 01/2018 - 10/2009
4	EndocannabinoidsIBA 01/2009 - 04/2007
4	Estrogens (Estrogen)FDA Link 02/2008 - 07/2002
3	Taurocholic Acid (Sodium Taurocholate)IBA 01/2022 - 05/2007
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2021 - 05/2010
3	Fast GreenIBA 01/2021 - 10/2016
3	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 11/2020 - 08/2011
3	Histidine (L-Histidine)FDA Link 01/2020 - 01/2018
3	Carboxy-LyasesIBA 01/2020 - 01/2018
3	Monoamine Oxidase (MAO)IBA 01/2020 - 11/2008
3	NF-kappa B (NF-kB)IBA 01/2019 - 08/2009
3	Arylalkylamine N-AcetyltransferaseIBA 01/2019 - 11/2014
3	Fibronectins (Fibronectin)IBA 01/2018 - 10/2016
3	Gonadotropin-Releasing Hormone (GnRH)FDA Link 11/2017 - 04/2015
3	Gonadal Steroid Hormones (Sex Hormones)IBA 10/2017 - 07/2009
3	Histidine DecarboxylaseIBA 10/2016 - 05/2012
3	ChemokinesIBA 01/2016 - 08/2009
3	Chloride-Bicarbonate AntiportersIBA 07/2013 - 04/2010
3	NeuropeptidesIBA 08/2011 - 07/2008
3	anandamide (arachidonylethanolamide)IBA 01/2009 - 04/2007
2	Adenosine Monophosphate (AMP)IBA 01/2022 - 07/2013
2	Choline (Choline Chloride)IBA 01/2022 - 10/2021
2	indoleIBA 01/2022 - 10/2020
2	Melatonin Receptors (Melatonin Receptor)IBA 01/2022 - 10/2011
2	Methionine (L-Methionine)FDA Link 01/2022 - 10/2021
2	Cholinergic Agents (Cholinergics)IBA 01/2022 - 10/2007
2	Biomarkers (Surrogate Marker)IBA 07/2021 - 12/2019
2	4- oxo- 6- ((pyrimidin- 2- ylthio)methyl)- 4H- pyran- 3- yl 4-nitrobenzoateIBA 01/2021 - 01/2017
2	Cyclic AMP (AMP, Cyclic)IBA 01/2021 - 12/2005
2	SynaptophysinIBA 01/2021 - 10/2016
2	DesminIBA 01/2021 - 01/2020
2	Apelin ReceptorsIBA 01/2021 - 01/2017
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 10/2016
2	ApelinIBA 01/2021 - 01/2017
2	Insulin (Novolin)FDA Link 01/2021 - 12/2018
2	Small Interfering RNA (siRNA)IBA 11/2020 - 10/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 04/2020
2	Keratin-19 (Keratin 19)IBA 01/2020 - 11/2016
2	Tryptophan HydroxylaseIBA 01/2020 - 11/2008

Therapy/Procedure

23	Therapeutics 12/2021 - 04/2006
21	Ligation 01/2019 - 10/2004
3	Denervation 01/2022 - 05/2007
3	Liver Transplantation 01/2017 - 05/2002
2	Immunotherapy 01/2022 - 01/2020
2	Radiotherapy 07/2021 - 11/2008
2	Drug Therapy (Chemotherapy) 07/2021 - 11/2008